Programme

Thursday 1st May 2008

08.30 REGISTRATION AND REFRESHMENTS

Session 1 – MLL

09.20 Welcome

09.30 Michael Cleary, Stanford University Medical School, California
Molecular and cellular features of MLL leukaemia stem cells

10.10 Scott Armstrong, Dana Farber Cancer Institute, Boston
Genomic approaches in MLL-rearranged leukaemias

10.50 Tea and Coffee

11.10 Jay Hess, University of Michigan
Mechanisms of transformation by MLL fusion proteins

11.50 Yali Dou, University of Michigan

Co-ordinated functions of chromatin modifying enzymes
12.30 Patricia Ernst , Dartmouth Medical School
Roles of the MLL Proto-Oncogene in Sustaining Adult Hematopoiesis

13.10 Lunch

Session 2 – Congenital Syndromes

14.00 Charlotte Niemeyer, University of Freiburg
JMML – is it all about Ras?

14.40 Kevin Shannon, University of California
Targeting Hyperactive Ras in haematologic cancers

15.20 Alan D'Andrea, Dana Farber Cancer Institute, Boston
The molecular pathogenesis in Fanconi Anaemia

16.00 Tea and Coffee

16.20 Inderjeet Dokal, Queen Mary's London
Dyskeratosis congenital: a disorder of telomerase dysfunction

17.00 Shai Izraeli, Sheba Medical Centre, Tel Hashomer, Israel
Lyndal Kearney, Institute of Cancer Research, London
Molecular genetics of ALL in Down's Syndrome

19.00 Dinner at The Crypt

Friday 2nd May 2008

Session 3 – Stem Cells

9.30 Tsvee Lapidot, Weizmann Institute of Science, Israel
Regulation of stem cell migration, retention and development

10.10 Sten Eirik Jacobsen University of Oxford
Identification, characterisation and surveillance of leukaemic stem cells

10.50 Tea and Coffee

11.10 Frederic Barabe, CHUL, Quebec
Modelling leukaemogenesis in human haematopoietic stem cells

11.50 Stuart Orkin, Children’s Hospital, Boston
GATA1, Down Syndrome, M7 Leukaemia and stem cells

12.30 Yair Riesner, Weizmann Institute of Science, Israel
Haematopoeitic stem cell transplantation across major genetic barriers

13.10 Lunch

Session 4 – Childhood Leukaemia in the post-genomic age

14.00 Stephen Hunger, University of Colorado School of Medicine
Integrating genomics into clinical trials for childhood ALL

14.40 Kjeld Schmiegelow University of Copenhagen
ALL epidemiology, case reports and molecular biology: their role in understanding common childhood ALL

15.20 Tea and Coffee

15.40 Jacques van Dongen, Erasmus University, Rotterdam
Title tbc

16.20 Kimberley Stegmaier, Dana Farber Cancer Institute, Boston
Signature-based approaches to leukaemia discovery